TY - JOUR ID - 139008 TI - Environmental factors affecting the risk of breast cancer and the modulating role of vitamin D on this malignancy JO - Central Asian Journal of Environmental Science and Technology Innovation JA - CAJESTI LA - en SN - 2717-4034 AU - Ercisli, Muhammed Furkan AU - Kahrizi, Danial AU - Aziziaram, Zahra AD - Basaksehir Cam and Sakura City Hospital, Department of Gynecology and Obstetrics, University of Health Science, Istanbul, Turkey AD - Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran AD - Research and Development Department, Giga Biotics, San Diego, California, USA Y1 - 2021 PY - 2021 VL - 2 IS - 4 SP - 175 EP - 183 KW - breast cancer KW - Environmental Factors KW - Vitamin D KW - Vitamin D receptor KW - Genomic pathway KW - Non-genomic pathway DO - 10.22034/CAJESTI.2021.04.04 N2 - The term cancer is derived from the Greek word crab. The ancient Greek physician Hippocrates likened diffuse cancer to a crab. Although our understanding of the disease has improved since then, this explanation still seems appropriate. Breast cancer is the most common type of cancer in women worldwide and is the second leading cause of cancer-related death in women after lung cancer. The disease is affected by factors such as the genetic structure of hormonal profiles and different lifestyles. Geographical status, living status, age of marriage, obesity, and nutritional factors are among the environmental factors predisposing to breast cancer. Among dietary supplements, the protective effect of vitamin D on breast cancer has been confirmed. The inverse relationship between sun exposure and breast cancer mortality has been proven. The direct link between decreased serum vitamin D and an increased risk of breast cancer has also been confirmed. In some breast cancer cells, the active form of vitamin D increases the expression of adhesion molecules, which prevents cancer from invasion and metastasis. In addition, this active form has anti-angiogenic activity and can inhibit cancer cell invasion. In this review, we narrate the environmental factors affecting the risk of breast cancer and the modulating role of vitamin D in this malignancy. UR - http://www.cas-press.com/article_139008.html L1 - http://www.cas-press.com/article_139008_29818afd72ecfdd20563d4f96e4b21be.pdf ER -